In comparison, the untagged peptides required intervention closer to the time of viral inoculation to achieve a similar level of protection. Both cholesterol- and cholesterol-PEG 3-tagged peptides were able to protect chicken embryos from infection with different serotypes of NDV and IBV when administered 12 h prior to virus inoculation. In this study, we demonstrate that peptides modified with cholesterol or 3 U of polyethylene glycol (PEG 3) conjugated to the peptides' N termini showed even more promising antiviral activities when tested in animal models. In previous work, we designed peptides that showed potent inhibition of Newcastle disease virus (NDV) and infectious bronchitis virus (IBV) infections in chicken embryos.
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